HIGH RISK BREAST DISORDERS:

ADH

Pathology: Localized intraductal proliferation with some features of DCIS and a wide range of morphologies; Characterized by a complex architectural proliferation of epithelial cells (left side of image) with nearby calcifications.

Clinical significance: 4x risk of breast cancer compared to age-matched controls

Management: Surgical excision; chemoprevention should be considered

(Ikeda 2010, Georgian-Smith 2014, Sabel 2015)

MG calcs with bx of ADH